Bioinformatická a funkční charakterizace taxonomicky omezených genů

Mgr. Jiří KYSLÍK

Disertační práce

Abstract:

Evolutionary dynamics, generating novel phenotypic traits, embody an essential route to either lineage-specific adaptations or to the creation of endless forms in organisms. Understanding the evolution of such ultimate novelties requires the study of the origin and the role of the functional units in generating unique traits, which represent the taxon-specific genes (TRGs). Myxozoa, the endoparasitic cnidarians, have become a suitable model for the study of evolutionary innovations, with their example of single-celled novelty: polar capsules. This uniquelly evolved structure within the spore stage represents a lineage-specific analogy of cnidarian stinging cells (nematocyst). In Cnidaria, nematocysts contain several uniquely emerged genes, rendering the assembly of this complex structure. The prominent fraction represents minicollagens, extremely shortened structural peptides forming the wall and tubule during the nematocyst development. Unlike in Cnidaria, the role of TRGs such as minicollagens in myxozoan development is unknown. The thesis describes the evolution and functional characterization of minicollagens in Myxozoa. Using the bioinformatics and molecular approaches, we explored the diversity and genomic organization and comprehensively characterized minicollagen gene expressions during myxospore development and localization of minicollagens in the polar capsule.

Jazyk práce: angličtina

Datum vytvoření / odevzdání či podání práce: 29. 4. 2022

Obhajoba závěrečné práce

• Vedoucí: RNDr. Ivan Fiala, Ph.D.

JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH

Přírodovědecká fakulta

Doktorský studijní program / obor:
Biologie / Parazitologie